Endocrine Abstracts

Background: Neuroendocrine tumors present in the MEN-1 syndrome are usually located in pancreatic islets and more than 10% appear de novo, affecting any age group. The debut of a carcinoid tumor is rare, with a prevalence of 2% of bronchial carcinoid tumors. Materials and methods: We present the case of a 49-year-old woman referred from the Oncology clinic for the assessment of thyroid incidentalomas found in a follow-up CT scan of multifocal bronchial c...

Background and objective: Several trials showed that sensor-augmented pump (SAP) therapy is safe and effective to reduce hypoglycemic events and improve glicemic control with high treatment satisfaction. Nevertheless patient adherence and sensor use in trials usually decrease with time. Our objective was to evaluate metabolic control and adherence and sensor use after initiation of SAP in a clinical trial.Methods: In 2008 we recruited 25 patients in trea...

Non alcoholic steatohepatitis (EHNA) is diagnosed by hepatic biopsy. Its etiology is uncertain but obesity is present in 69–100% of all cases and type 2 diabetes mellitus (DM) in about 34–75%.Objectives: To study the prevalence of EHNA in morbidly obese patients and determine if there is a difference between the prevalence in patients with and without carbohydrate metabolism disorders.Patients and methods: Prospective stu...

Background. Abnormal lipoprotein composition associated with growth hormone deficiency (GHD) may contribute to increased mortality observed in conventionally replaced hypopituitarism. Aim. To examine the effects of forty weeks of growth hormone replacement (GHR) on lipoprotein composition and LDL size in sixteen GHD hypopituitary subjects. In eight patients, VLDL and LDL composition were additionally assessed after eight weeks. Methods. VLDL and LDL were separated by different...

Background and aims: INSmutations can cause INS-MODy and have been described more frequently in cases of neonatal diabetes mellitus. The reported phenotypic expression of INS-MODy is quite variable.Objective: To clinically, biochemically and molecularly characterize INS-MODy patients in two Spanish tertiary level hospitals during the period 2009-2023.Methods: Cross-sectional study that included 121 pediatric patients with ...

Objective: Our objective in this study was to identify the type of clinical care received by young type 1 diabetic patients who have made the transition from paediatric to adult care, and to assess the metabolic status of the patients. The research aimed to develop a sustainable and coordinated approach to facilitating the transition between diabetes services for adolescents and reveal from the perspective of the adolescents living with type 1 diabetes their experiences surrou...

Objective: Our objective in this study was to identify the type of clinical care received by young type 1 diabetic patients who have made the transition from paediatric to adult care, and to assess the metabolic status of the patients. The research aimed to develop a sustainable and coordinated approach to facilitating the transition between diabetes services for adolescents and reveal from the perspective of the adolescents living with type 1 diabetes their experiences surrou...

Background. Hypopituitarism is associated with increased VLDL and LDL apoB concentrations, which may be attributable to GHD. Studies examining the effects of GHR on VLDL apoB kinetics have been conflicting, possibly due to differences in the duration of GHR. As yet, the effects of GHR on LDL apoB kinetics are unknown. Aim. To examine the effect of GHR on VLDL and LDL apoB kinetics, and to explore the hypothesis that these effects are dependent on the duration of therapy. Metho...

Background: There aren’t published randomized studies comparing the clinical impact of degludec and Glragina U300 in the treatment of type 1 diabetes patients. (T1DP)Objective: To compare efficacy and safety of the new long acting analogues Glargine U 300 and Degludec in 300 Type1 diabetes patients treated with basal/bolus treatment.(BBT)Material and methods: Randomized control study 1.1 in 300 T1DP treated with BBT with glarg...

Introduction: Evidence suggests that, for the same mean glucose level, protein glycation may be different and that this may have an impact on the occurrence of complications. We currently have GMI that estimates mean glucose measured with the FreeStyle Libre 2 and HbA1c determined in the laboratory.Objectives: To analyse the proportion of “rapid glycaemic” patients in our clinical setting (HbA1c-GMI>0.5) and to assess the prevalence of micr...